Nanotechnology and the fight against breast cancer Breast Cancer is a heterogeneous disease that has been known since long time ago does not behave alike in all women. It is different in a young woman in an old woman, or whether it occurs before or after menopause, explains Ricardo Fernandez, medical director of the IOB Bilbao-Bizkaia (Instituto Oncologico Baselga). This ancient empirical knowledge has a molecular basis whose mechanisms were revealing over the last century, but in recent years has acquired a spectacular development that justifies much of the advances that have occurred in the progress of this disease, says the expert. Recently described genetic profiles allow you to choose the cancer treatments and define forecasts more accurately. In addition, the division into molecular subgroups developed this decade, whose incorporation into daily practice is very common, allows you to customize treatments available improving prognosis and reducing toxicities.
Now We select best hormone treatment, says Fernandez. Moreover, today met several genes (BRCA 1 and 2) familial breast cancer, allowing to select women with increased risk of suffering from this disease to increase preventive measures and a more precocious diagnostic tests, indicates the medical director of the Bilbao-Bizkaia IOB. -The emergence of nanotechnology applied to drug engineering has allowed the development of drugs that improve efficiency and reduce toxicity. -Also have been developed other anti-tumour drugs with a toxicity profile more favorable and better tolerated – whose mechanism of action is aimed at blocking the production of blood vessels that nourish the tumor so that the tumor cells die because they can not feed. -Breast cancer is a heterogeneous disease that has been known since long time ago does not behave alike in all women. -Division into molecular subgroups enables you to customize the treatments available against the breast cancer improving prognosis and reducing toxicities. -Several genes involved in familial breast cancer, allowing to select women with increased risk of suffering from this disease to increase preventive measures, the chances of finding a cure for cancer and tests are known more effective for more early diagnosis. -Treatments of support, to improve defenses, anaemia, reduce the vomiting, strengthen bones also have experienced an important development in this decade, which facilitates the management of this disease.
Some antitumor drugs not only knows better the biology of the tumor cell, but also the environment in which the cell grows. Thus, we have developed drugs whose mechanism of action is aimed at blocking the production of blood vessels that nourish the tumor (antiangiogenic drugs) so that the tumor cells die because they can not feed. Given that these drugs are directed against specific targets, they have also a different, better tolerated and more favorable toxicity profile. Another recent developments is the emergence of nanotechnology applied to drug engineering. According to the expert, have developed drugs that have come into use this year in Europe, and from a known molecule and adding nanoparticles to it, improve its efficacy and toxicity profile. This is a newly opened field that has enormous potential to achieve a possible cure for cancer. Also, new families of drugs are emerging, with different mechanisms of action that extend the therapeutic weaponry and known drugs are administered now by the oral route, facilitating their administration. Finally, treatments to improve defenses, anemia, support reduce the vomiting, strengthen bones also have experienced an important development in this decade what facilitates the handling of the disease, concludes Dr.